NAD can restore mitochondrial function and energy production in MTDPS liver-like cells

Reposted from Science Daily

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Mitochondria are responsible for supplying the cell with energy in the form of ATP through oxidative phosphorylation. There is a group of rare, autosomal recessive disorders, known as Mitochondrial DNA Depletion Syndromes (MTDPS), which causes a significant reduction in mitochondrial DNA (mtDNA) and ATP production. There is no treatment for MTDPS, and it is typically fatal during infancy as a result of liver failure. Researchers at the Medical University of South Carolina (MUSC) have identified several drug candidates for the treatment of MTDPS. Their results, published online in the November 6, 2018 issue of Cell Reports, showed that nicotinamide adenine dinucleotide (NAD) significantly restored mitochondrial function in vitro as well as in preclinical animal models.

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