Dietary Supplement Can Help Maintain NAD Levels in Aging Patients

Reposted from thedoctorschannel.com

 

Nicotinamide adenine dinucleotide (NAD) and its related coenzyme NADP+ are vital within cells for oxidative energy production and resisting stress from reactive oxygen species. The ability to produce NAD via NAD metabolism (a.k.a. the NAD metabolome) declines with age. Therefore, supplementing with NAD precursors can help maintain or increase NAD levels if/when necessary.

Cells have four precursors from which NAD can be produced via the NAD metabolome: tryptophan (amino acid), niacin/nicotinic acid (vitamin), nicotinamide (vitamin), and nicotinamide riboside (vitamin). Nicotinamide riboside (NR) appears to be the best choice for an NAD precursor supplement because the genes and enzymes required to convert it to NAD are expressed in virtually all cells and tissues. This is not the case with tryptophan or niacin/nicotinic acid.

NR does not cause flushing at high doses (unlike niacin/nicotinic acid), and it does not inhibit the protective sirtuin enzymes that are important in longevity at high doses, unlike nicotinamide.

In The NewsANAD Staff