AboutNAD

Dr. Charles Brenner is the Alfred E Mann Family Foundation Chair in Diabetes and Cancer Metabolism at City of Hope. Brenner is the leading global scholar on the topic of synthesis, regulation and quantification of NAD coenzymes and NAD metabolites in health and disease.

In 2004, Brenner, then a faculty member at Dartmouth College, discovered nicotinamide riboside (NR) to be a vital precursor of nicotinamide adenine dinucleotide (NAD+), which is made available by nicotinamide riboside kinases (Nrks) that are conserved between yeast and humans.

Brenner has made multiple seminal contributions to NAD+ metabolism, which include engineering a yeast strain to convert inexpensive NAD+ precursor vitamins into NR, solving the crystal structure of human Nrk1, developing the methods for quantitative NAD+ metabolomics, and demonstrating the activity of oral NR in animal models of fatty liver disease, obesity, type 2 diabetes, diabetic and chemotherapeutic neuropathy, heart failure, central brain injury, COVID and postpartum. Dr. Brenner also led the first clinical trial of NR, which established safe oral availability in humans. Brenner collaborates with research groups globally who are investigating activities of NR in reducing inflammation and improving human health and resistance to disease.

His research group at City of Hope is now focused on dissecting and treating the rare disease of Citrin Deficiency, which inactivates one of the key shuttle systems for NADH.

Dr. Bohr is one of the world’s most published researchers on aging and neurodegenerative disease with over 624 journal publications. For the past 30 years, Dr. Bohr served as Chief of the Laboratory of Molecular Genetics at the National Institute on Aging, which is part of the National Institutes of Health.

Dr. Bohr earned his M.D., Ph.D. and D.Sc. degrees at the University of Copenhagen, Denmark. After training in neurology and infectious diseases at the University Hospital in Copenhagen, Dr. Bohr undertook postdoctoral studies in Biochemistry in the laboratory of Dr. Hans Klenow at the University of Copenhagen, where he first became interested in nucleic acid metabolism. He developed this interest further in the laboratory of Dr. Philip Hanawalt at Stanford University where he held a Visiting Scholar position. Throughout his career, Dr. Bohr has made significant contributions and advanced understanding of DNA repair pathways, mechanisms and cellular response to oxidative DNA damage and oxidative stress.

In his recent studies, Dr. Bohr has made seminal findings about the relationships between DNA damage, DNA repair capacity and age-associated neurodegeneration. Additionally, he has proposed important models describing the transfer of signals between the nuclear and mitochondrial genomes, and showcased the importance of energy homeostasis/imbalance and mitochondrial dysfunction in aging-related neurodegenerative disease. Although retiring from the National Institutes of Health, Dr. Bohr maintains a research lab at the University of Copenhagen where he will continue to study the benefits of NR.

Toby Amidor is the founder of Toby Amidor Nutrition, PC, where she provides nutrition and food safety consulting services for individuals, restaurants and food brands. She is a Wall Street Journal bestselling cookbook author with 11 published cookbooks and has served as the nutrition expert for FoodNetwork.com for close to 18 years, where she was a founding contributor to their Healthy Eats Blog.

As a nutrition expert, Toby regularly contributes to major publications including MensFitness.com, Shape.com, EatThis.com, and US News Health, and maintains her own "Ask the Expert" column in Today's Dietitian Magazine. She serves on the medical board for Forbes.com and EatThis.com and on the editorial board for Today's Dietitian Magazine. She has been quoted in hundreds of publications and appears regularly on local and national television shows.

Toby trained as a clinical dietitian at New York University and served as an adjunct professor at Teachers College, Columbia University for 11 years, also teaching at CUNY Hunter School of Public Urban Health and CUNY Lehman College. Through her consulting and faculty positions, she has established herself as a leading expert in culinary nutrition, food safety, and media communications. In 2018, Toby was awarded the coveted Media Excellence Award by the Academy of Nutrition & Dietetics.

Dr. Philip Redpath is the Director of Innovation, R&D at Niagen Bioscience, where he leads scientific research in synthetic chemistry, analytical development, and NAD+ precursor research. A synthetic organic chemist by training, he earned his Ph.D. from Queen's University Belfast and brings over a decade of specialized experience in developing methodologies to produce NAD+ precursors and stable isotopically labeled compounds for metabolomic research.

Since joining the field in 2017, Dr. Redpath has collaborated with leading NAD+ scientists worldwide, contributing to studies that have advanced understanding of the bioavailability, biodistribution, and metabolic fate of NAD+ precursors. His research has supported high-impact studies exploring NAD+ metabolism in healthy aging and disease prevention through one of the largest external research programs of its kind.

Dr. Redpath has authored numerous peer-reviewed publications and is a named inventor on over 60 internationally-granted patents related to NAD+ research. His work focuses on translational science that bridges laboratory discoveries with practical applications in the study of cellular health and NAD+ metabolism.

Lauren Manaker is a registered dietitian and three-time author with a focus on women's health nutrition. With over 22 years of experience, she has established herself as a trusted voice in translating complex nutrition science into actionable guidance for both individuals and the broader public.

As a three-time published author and sought-after speaker, Lauren contributes regularly to major media outlets and serves as a medical reviewer, ensuring accurate and reliable nutrition information reaches audiences nationwide. Her expertise has made her a go-to resource for journalists, brands, and healthcare professionals seeking evidence-based perspectives on nutrition and wellness.

Lauren has held leadership positions within the Academy of Nutrition and Dietetics and serves on advisory boards for dietetic education programs and media organizations, where she helps shape the next generation of nutrition professionals and public health communications. Her commitment to mentorship extends beyond the professional realm, volunteering with a nonprofit organization supporting young women in foster care, reflecting her dedication to empowering women at every stage of life.

Dr. Michael Sagner is a distinguished physician and internationally recognized expert in longevity and preventive medicine. As Clinical Advisor in Longevity and Preventive Medicine at Ageing Research at King's (ARK) and founder of The Serena Clinic—with locations in Los Angeles, London, and Monaco—he has dedicated his career to translating cutting-edge science into precision strategies that extend healthspan and optimize human performance.

Over decades of clinical practice and research, Dr. Sagner has established himself as one of the foremost authorities on life longevity, providing elite patient care, advising governments, and shaping international standards for preventive medicine. His expertise spans systems biology, endocrinology, metabolism, and sports medicine, with particular focus on advancements in NAD+ metabolism and cellular resilience as foundations for healthy aging.

Dr. Sagner serves as Founder and Executive Director of the European Society of Preventive Medicine and holds influential advisory positions with leading health organizations worldwide. He is a partner of the European Innovation Partnership on Active and Healthy Aging and has contributed to policy development with the European Union Platform for Action on Diet, Physical Activity and Health and the UK All Parliamentary Group for Longevity. His collaborations with the World Health Organization (WHO), World Heart Federation, and World Obesity Federation have advanced the "cell to community" model of prevention, bridging molecular science with population health.

A Fellow of the Royal Society of Medicine, Dr. Sagner continues to lead the evolution of personalized, science-driven longevity care through his clinical leadership at The Serena Clinic, his research contributions, and his advocacy for NAD+-based interventions. His work advising international health bodies and policymakers helps shape standards for healthy aging worldwide, establishing his legacy as a visionary in the field of preventive and longevity medicine.