Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration.
Abstract NAD depletion is a common phenomenon in neurodegenerative pathologies. Excitotoxicity occurs in multiple neurologic disorders and NAD was shown to prevent neuronal degeneration in this process [...]
Background Congenital malformations can be manifested as combinations of phenotypes that co-occur more often than expected by chance. In many such cases, it has proved [...]
Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells
Objective Boosting nicotinamide adenine dinucleotide (NAD) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside [...]
Nicotinamide riboside, a form of vitamin B3 and NAD precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats.
Abstract Injury to sensory afferents may contribute to the peripheral neuropathies that develop after administration of chemotherapeutic agents. Manipulations that increase levels of nicotinamide adenine [...]
Nicotinamide riboside, a form of vitamin B3 and NAD precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats
Published in Journal of the International Association for the Study of Pain (PAIN). Injury to sensory afferent nerves may contribute to the peripheral neuropathies that [...]
A NAD-dependent transcriptional program governs self-renewal and radiation resistance in glioblastoma
Published in PNAS. Accumulating evidence suggests cancer cells exhibit a dependency on metabolic pathways regulated by nicotinamide adenine dinucleotide (NAD). Nevertheless, how the regulation of [...]