1906 – NAD+ was discovered by Arthur Harden and William John Young.
Just a few years before Harden and Young’s discovery of NAD+, Louis Pasteur had shown…Read more
1929 – Hans von Euler-Chelpin won the Nobel Prize with Arthur Harden for their investigation into fermentation
Originally a student of art, Hans von Euler-Chelpin continued Harden and Young’s work by studying…Read more
1936 – Otto Heinrich Warburg showed how NAD+ functions in fermentation reactions.
Otto Heinrich Warburg studied the chemistry of the fermentation reactions and discovered that the co-enzyme…Read more
1938 – Conrad Elvehjem discovered “anti-black tongue factor,” the first vitamin precursors of NAD+.
In the early 1900s, Pellagra was a common disease that caused symptoms such as diarrhea…Read more
1940 – Arthur Kornburg discovered the first NAD+ biosynthetic enzyme.
After Hans von Euler-Chelpin’s early purification of NAD+ and Conrad Elvehjem’s discovery of nicotinic acid…Read more
1958 – Jack Preiss and Philip Handler discovered the pathway through which nicotinic acid is converted into NAD+.
Since Conrad Elvehjem showed that nicotinic acid was the agent that prevented pellagra and Arthur…Read more
1963 – Mandel and colleagues described the first chemical reaction in which NAD+ is broken down to its component parts.
Research up to this point had shown that NAD+ was important for fermentation in yeast…Read more
2000 – Leonard Guarente and co-workers discovered that Sirtuin enzymes break NAD+ into its component parts.
Sirtuin enzymes were discovered in yeast for their exciting ability to extend the lifespan of…Read more
2004 – Charles Brenner and co-workers discovered a new NAD+ precursor and the pathway through which nicotinamide riboside is converted into NAD+.
Like the discoveries of nicotinic acid by Conrad Elvehjem and Priess and Handler, Brenner and…Read more