History on NAD 2018-03-12T11:20:03+00:00

1906 – NAD was discovered by Arthur Harden and William John Young.

1906 – NAD was discovered by Arthur Harden and William John Young.

Just a few years before Harden and Young’s discovery of NAD, Louis Pasteur had shown…

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1929 – Hans von Euler-Chelpin won the Nobel Prize with Arthur Harden for their investigation into fermentation

1929 – Hans von Euler-Chelpin won the Nobel Prize with Arthur Harden for their investigation into fermentation

Originally a student of art, Hans von Euler-Chelpin continued Harden and Young’s work by studying…

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1936 – Otto Heinrich Warburg showed how NAD functions in fermentation reactions.

1936 – Otto Heinrich Warburg showed how NAD functions in fermentation reactions.

Otto Heinrich Warburg studied the chemistry of the fermentation reactions and discovered that the co-enzyme…

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1938 – Conrad Elvehjem discovered “anti-black tongue factor,” the first vitamin precursors of NAD.

1938 – Conrad Elvehjem discovered “anti-black tongue factor,” the first vitamin precursors of NAD.

In the early 1900s, Pellagra was a common disease that caused symptoms such as diarrhea…

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1940 – Arthur Kornberg discovered the first NAD biosynthetic enzyme.

1940 – Arthur Kornberg discovered the first NAD biosynthetic enzyme.

After Hans von Euler-Chelpin’s early purification of NAD and Conrad Elvehjem’s discovery of nicotinic acid as…

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1958 – Jack Preiss and Philip Handler discovered the pathway through which nicotinic acid is converted into NAD.

1958 – Jack Preiss and Philip Handler discovered the pathway through which nicotinic acid is converted into NAD.

Since Conrad Elvehjem showed that nicotinic acid was the agent that prevented pellagra and Arthur…

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1963 – Mandel and colleagues described the first chemical reaction in which NAD is broken down to its component parts.

1963 – Mandel and colleagues described the first chemical reaction in which NAD is broken down to its component parts.

Research up to this point had shown that NAD was important for fermentation in yeast and…

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2000 – Leonard Guarente and co-workers discovered that Sirtuin enzymes break NAD into its component parts.

2000 – Leonard Guarente and co-workers discovered that Sirtuin enzymes break NAD into its component parts.

Sirtuin enzymes were discovered in yeast for their exciting ability to extend the lifespan of…

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2004 – Charles Brenner and co-workers discovered a new NAD precursor and the pathway through which nicotinamide riboside is converted into NAD.

2004 – Charles Brenner and co-workers discovered a new NAD precursor and the pathway through which nicotinamide riboside is converted into NAD.

Like the discoveries of nicotinic acid by Conrad Elvehjem and Priess and Handler, Brenner and…

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What environmental factors impact NAD levels?

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