History on NAD 2018-01-30T15:35:16+00:00

1906 – NAD+ was discovered by Arthur Harden and William John Young.

1906 – NAD<sup>+</sup> was discovered by Arthur Harden and William John Young.

Just a few years before Harden and Young’s discovery of NAD+, Louis Pasteur had shown…

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1929 – Hans von Euler-Chelpin won the Nobel Prize with Arthur Harden for their investigation into fermentation

1929 – Hans von Euler-Chelpin won the Nobel Prize with Arthur Harden for their investigation into fermentation

Originally a student of art, Hans von Euler-Chelpin continued Harden and Young’s work by studying…

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1936 – Otto Heinrich Warburg showed how NAD+ functions in fermentation reactions.

1936 – Otto Heinrich Warburg showed how NAD<sup>+</sup> functions in fermentation reactions.

Otto Heinrich Warburg studied the chemistry of the fermentation reactions and discovered that the co-enzyme…

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1938 – Conrad Elvehjem discovered “anti-black tongue factor,” the first vitamin precursors of NAD+.

1938 – Conrad Elvehjem discovered “anti-black tongue factor,” the first vitamin precursors of NAD<sup>+</sup>.

In the early 1900s, Pellagra was a common disease that caused symptoms such as diarrhea…

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1940 – Arthur Kornburg discovered the first NAD+ biosynthetic enzyme.

1940 – Arthur Kornburg discovered the first NAD<sup>+</sup> biosynthetic enzyme.

After Hans von Euler-Chelpin’s early purification of NAD+ and Conrad Elvehjem’s discovery of nicotinic acid…

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1958 – Jack Preiss and Philip Handler discovered the pathway through which nicotinic acid is converted into NAD+.

1958 – Jack Preiss and Philip Handler discovered the pathway through which nicotinic acid is converted into NAD<sup>+</sup>.

Since Conrad Elvehjem showed that nicotinic acid was the agent that prevented pellagra and Arthur…

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1963 – Mandel and colleagues described the first chemical reaction in which NAD+ is broken down to its component parts.

1963 – Mandel and colleagues described the first chemical reaction in which NAD<sup>+</sup> is broken down to its component parts.

Research up to this point had shown that NAD+ was important for fermentation in yeast…

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2000 – Leonard Guarente and co-workers discovered that Sirtuin enzymes break NAD+ into its component parts.

2000 – Leonard Guarente and co-workers discovered that Sirtuin enzymes break NAD<sup>+</sup> into its component parts.

Sirtuin enzymes were discovered in yeast for their exciting ability to extend the lifespan of…

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2004 – Charles Brenner and co-workers discovered a new NAD+ precursor and the pathway through which nicotinamide riboside is converted into NAD+.

2004 – Charles Brenner and co-workers discovered a new NAD<sup>+</sup> precursor and the pathway through which nicotinamide riboside is converted into NAD<sup>+</sup>.

Like the discoveries of nicotinic acid by Conrad Elvehjem and Priess and Handler, Brenner and…

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